Effects of vitamin E on the aggregation and the lipid peroxidation of platelets exposed to hydrogen peroxide.

HIGASHI, 0. and KIKUCHI, Y. Effects of Vitamin E on the Aggregation and the Lipid Peroxidation of Platelets exposed to Hydrogen Peroxide. I Tohoku J. exp. Med., 1974, 112 (3), 271-278 -The hydrogen peroxide (11202)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggrega tion could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed to H202 could also be inhibited by vitamin E-nicotinate. The lipid peroxide formation associated with membrane disruption may be involved in the mechanism underlying the H2O2-induced platelet aggregation. vitamin E-nicotinate; platelet aggregation; hydrogen peroxide; thrombosis; lipid peroxidation